HOME | 研究業績

研究業績

発表論文

2018

  • Torii S, Kubota C, Saito N, Kawano A, Hou N, Kobayashi M, Torii R, Hosaka M, Kitamura T, Takeuchi T, Gomi H.  The pseudophosphatase phogrin enables glucose-stimulated insulin signaling in pancreatic β-cells. J Biol Chem 293: 5920-5933, 2018 

  • Maeda Y, Kudo S, Tsushima K, Sato E, Kubota C, Kayamori A, Bochimoto H, Koga D, Torii S, Gomi H, Watanabe T, Hosaka M. Impaired processing of prohormones in secretogranin III null mice causes maladaptation to an inadequate diet and stress. Endocrinology 159: 1213-1227, 2018

2017
  • Gomi H, Osawa H, Uno R, Yasui T, Hosaka M, Torii S, Tsukise A. Canine Salivary Glands: Analysis of Rab and SNARE Protein Expression and SNARE Complex Formation With Diverse Tissue Properties. J Histochem Cytochem 65: 637-653, 2017 

  • Shintoku R, Takigawa Y, Yamada K, Kubota C, Yoshimoto Y, Takeuchi T. Koshiishi I, Torii S. Lipoxygenase-mediated generation of lipid peroxides enhances ferroptosis induced by erastin and RSL3. Cancer Sci 108: 2187-2194, 2017 

  • Nakakura T, Suzuki T, Torii S, Asano-Hoshino A, Nekooki-Machida Y, Tanaka H, Arisawa K, Nishijima Y, Susa T, Okazaki T, Kiuchi Y, Hagiwara H. ATAT1 is essential for regulation of homeostasis-retaining cellular responses in corticotrophs along hypothalamic-pituitary-adrenal axis. Cell Tissue Res 370: 169-178, 2017

2016
  • Torii S, Shintoku R, Kubota C, Yaegashi M, Torii R, Sasaki M, Suzuki T, Mori M, Yoshimoto Y, Takeuchi T. Yamada K. An essential role for functional lysosomes in ferroptosis of cancer cells. Biochem J 473: 769-777, 2016.
  • Aoyagi K, Ohara-Imaizumi M, Itakura M, Torii S, Akimoto Y, Nishiwaki C, Nakamichi Y, Kishimoto T, Kawakami H, Harada A, Takahashi M, Nagamatsu S. VAMP7 regulates autophagy to maintain mitochondrial homeostasis and to control insulin secretion in pancreatic β-cells. Diabetes 65: 1648-1659, 2016.
2015
  • Gomi H, Morikawa S, Shinmura N, Moki H, Yasui T, Tsukise A, Torii S, Watanabe T, Maeda Y, Hosaka M. Expression of secretogranin III in chicken endocrine cells: Its relevance to the secretory granule properties of peptide prohormone processing and bioactive amine contents. J Histochem Cytochem 63, 350-366, 2015.
2013
  • Sun M, Watanabe T, Bochimoto H, Sakai Y, Torii S, Takeuchi T, Hosaka M. Multiple sorting systems for secretory granules ensure the regulated secretion of peptide hormones. Traffic 14, 205-218 (2013).
  • Gomi H, Kubota-Murata C, Yasui T, Tsukise A, Torii S . Immunohistochemical analysis of IA-2 family of protein tyrosine phosphatases in rat gastrointestinal endocrine cells. J Histochem Cytochem 61, 156-168 (2013).
2012
  • Hou N, Mogami H, Kubota-Murata C, Sun M, Takeuchi T, Torii S. Preferential release of newly synthesized insulin assessed by a multi-label reporter system using pancreatic β-cell line MIN6. PLoS One 7, e47921 (2012).
2011
  • Yamaguchi R, Hosaka M, Torii S, Hou N, Saito N, Yoshimoto Y, Imai H, Takeuchi T. Cyclophilin C-associated protein regulation of phagocytic functions via NFAT activation in macrophages. Brain Res 1397, 55-65 (2011).
  • Saito, N., Takeuchi, T., Kawano, A., Hosaka, M., Hou, N., Torii, S.: Luminal Interaction of Phogrin with Carboxypeptidase E for Effective Targeting to Secretory Granules. Traffic 12, 499-506 (2011).
2010
  • Tsuchiya, M., Hosaka, M., Moriguchi, T., Zhang, S., Suda, M., Yokota-Hashimoto, H., Shinozuka, K., Takeuchi, T. (The first two authors contributed equally to this work.): Cholesterol Biosynthesis Pathway Intermediates and Inhibitors Regulate Glucose-stimulated Insulin Secretion and Secretory Granule Formation in Pancreatic beta-Cells. Endocrinology 151, 4705-4716.
  • Zhang, S., Hosaka, M., Yoshihara, T., Negishi, K., Iida, Y., Tobita, S., Takeuchi, T. (The first three authors contributed equally to this work.): Phosphorescent Light-emitting Iridium Complexes Serve as a Hypoxia-sensing Probe for Tumor Imaging in Living Animals. Cancer Reserch 70, 4490-4498.
  • Hosaka M, Watanabe T: Secretogranin III: a bridge between core hormone aggregates and the secretory granule membrane. Endocrine J. 57, 275-286.
  • Kubota C, Torii S, Hou N, Saito N, Yoshimoto Y, Imai H, Takeuchi T.: Constitutive reactive oxygen species generation from autophagosome/lysosome in neuronal oxidative toxicity. J. Biol. Chem. 285, 667-674.
2009
  • Moriguchi, T., Hosaka, M., Yosinari, A., Ozaki, A., Takeuchi, T., Shinozuka, K.: Cholesterol Analogs Labeled with Novel Silylated Fluorescent Compounds. Chemistry Letters 38, 966-967.
  • Hotta, K., Hosaka, M., Tanabe, A., Takeuchi, T. (The first two authors contributed equally to this work.): Secretogranin II Binds to Secretogranin III and Forms Secretory Granules with Orexin, Neuropeptide Y and Proopiomelanocortin. J. Endocrinol. 202, 111-121.
  • Torii S, Saito N, Kawano A, Hou N, Ueki K, Kulkarni RN, Takeuchi T.: Gene silencing of phogrin unveils its essential role in glucose-responsive pancreatic beta-cell growth. Diabetes 58, 682-692.
  • Torii S.: Expression and function of IA-2 family proteins, unique neuroendocrine-specific protein-tyrosine phosphatases. Endocrine J. 56, 639-648.
2008
  • Han, L., Suda, M., Tsuzuki, K., Wang, R., Ohe, Y., Hirai, H., Watanabe, T., Takeuchi, T., Hosaka, M.: A large form of secretogranin III functions as a sorting receptor for chromogranin A aggregates in PC12 cells. Mol. Endocrinol. 22, 1935-1949.
  • Hou, N., Torii, S., Saito, N., Hosaka, M., Takeuchi, T.: Reactive Oxygen Species-Mediated Pancreatic beta-Cell Death Is Regulated by Interactions between Stress-Activated Protein Kinases, p38 and c-Jun N-Terminal Kinase, and Mitogen-Activated Protein Kinase Phosphatases. Endocrinology. 149, 1654-1665.
  • Takeuchi, T., Hosaka, M.: Sorting Mechanism of Peptide Hormones and Biogenesis Mechanism of Secretory Granules by Secretogranin III, a Cholesterol-Binding Protein, in Endocrine Cells. Curr. Diabetes Rev. 4, 31-38.
  • Chavas LM, Ihara K, Kawasaki M, Torii S, Uejima T, Kato R, Izumi T, Wakatsuki S.: Elucidation of Rab27 Recruitment by Its Effectors: Structure of Rab27a Bound to Exophilin4/Slp2-a. Structure 16, 1468-1477.
2007
  • Kitahara, K., Sakai, Y., Hosaka, M., Hira, Y., Kakizaki, H., Watanabe, T.: Effects of a depot formulation of the GnRH agonist leuprorelin on the ultrastructure of male rat pituitary gonadotropes. Arch Histol Cytol. 70, 79-93.
  • Hosaka, M., Watanabe, T., Yamauchi, Y., Sakai, Y., Suda, M., Mizutani, S., Takeuchi, T., Isobe, T., Izumi, T.: A subset of p23 localized on secretory granules in pancreatic beta-cells. J. Histochem. Cytochem. 55, 235-245.
  • Yu M, Kasai K, Nagashima K, Torii S, Yokota-Hashimoto H, Okamoto K, Takeuchi T, Gomi H, Izumi T.: Exophilin4/Slp2-a targets glucagons granules to the plasma membrane through unique Ca 2+ -inhibitory phospholipids-binding activity of the C2A domain. Mol. Biol. Cell 18: 688-696.
  • Chavas LM, Torii S, Kamikubo H, Kawasaki M, Ihara K, Kato R, Kataoka M, Izumi T, Wakatsuki S.: Structure of the small GTPase Rab27b shows an unexpected swapped dimer. Acta Crystallogr D Biol Crystallogr. 63 (Pt 7), 769-779.
2006
  • Wang, R., Hosaka, M., Han, L., Yokota-Hashimoto, H., Suda, M., Mitsushima, D., Torii, S., Takeuchi, T.: Molecular probes for sensing the cholesterol composition of subcellular organelle membranes. Biochim. Biophys. Acta. 1761, 1169-1181.
  • Croxton R, Puto LA, Belle I, Thomas M, Torii S, Hanaii F, Cuddy M, and Reed JC.: Daxx represses expression of a subset of anti-apoptotic genes regulated by Nuclear Factor-{kappa}B. Cancer Res. 66, 9026-9035.
2005
  • Hosaka, M., Watanabe, T., Sakai, Y., Kato, T., Takeuchi, T.: Interaction between secretogranin III and carboxypeptidase E facilitates prohormone sorting within secretory granules. J. Cell Science 118, 4785-4795.
  • Sakai Y, Hosaka M, Hira Y, Watanabe T.: Addition of phosphotungstic acid to ethanol for dehydration improves both the ultrastructure and antigenicity of pituitary tissue embedded in LR White acrylic resin. Arch Histol Cytol. 68, 337-347.
  • Torii S, Saito N, Kawano A, Zhao S, Izumi T, Takeuchi T.: Cytoplasmic transport signal of phogrin is involved in its targeting and localization to secretory granule. Traffic 6, 1213-1224.
  • Izumi T, Gomi H, and Torii S.: Functional analysis of granuphilin in insulin exocytosis. Methods Enzymol. 403, 216-229.
 
2004
  • Aihara, M., Sugawara, K., Torii, S., Hosaka, M., Kurihara, H., Saito, N., Takeuchi, T.: Angiogenic Endothelium-specific Nestin Expression is enhanced by the First Intron of the Nestin Gene. Lab. Invest. 84, 1581-1592.
  • Sakai, Y., Hosaka, M., Yoshinaga, A., Hira, Y., Harumi, T., Watanabe, T. :Immunocytochemical localization of secretogranin III in the endocrine pancreas of male rats. Arch Histol Cytol. 67, 57-64.
  • Fujisawa, T., Kamimura, H., Hosaka, M., Torii, S., Izumi, T., Kuwano, H., Takeuchi, T.: Functional localization of proprotein-convertase furin and its substrate TGF in EGF receptor-expressing gastric chief cells. Growth Factors 22, 51-59.
  • Hosaka, M., Suda, M., Sakai, Y., Izumi, T, Watanabe, T., Takeuchi, T.: Secretogranin III binds to cholesterol in the secretory granule membrane as an adapter for chromogranin A. J. Biol. Chem. 30, 3627-3634.
  • Torii S, Takeuchi T, Nagamatsu S, Izumi T. Rab27 effector granuphilin promotes the plasma membrane targeting of insulin granules via interaction with syntaxin 1a. J. Biol. Chem. 279, 22532-22538.
 
2003
  • Zhang, B., Hosaka, M., Sawada, Y., Torii, S., Mizutani, S., Ogata, M., Izumi, T., Takeuchi, T.: PTHrP induces insulin expression through activation of MAP kinase-specific phosphatase-1 that dephosphorylates c-jun N-terminal kinase in pancreatic beta-cells. Diabetes 52, 2720-2730.
  • Sakai, Y., Hosaka, M., Hira, Y., Harumi, T., Ohsawa, Y., Wang, H., Takeuchi, T., Uchiyama, Y., Watanabe, T.: Immunocytochemical localization of secretogranin III in the anterior lobe of male rat pituitary glands. J. Histochem. Cytochem. 51, 227-238.
  • Izumi T, Gomi H, Kasai K, Mizutani S, Torii S. Roles of rab27 and its effectors in the regulated secretory pathways. Cell Struct. Funct. 28, 465-474.
2002
  • Hosaka, M., Watanabe, T., Sakai, Y., Uchiyama, Y., Takeuchi, T.: Identification of a chromogranin A domain that mediates binding to secretogranin III and targeting to secretory granules in pituitary cells and pancreatic -Cells. Mol. Biol. Cell 13, 3388-3399.
  • Yi, Z., Yokota, H., Torii, S., Aoki, T., Hosaka, M., Zhao, S., Takata, K., Takeuchi, T., Izumi, T.: The rab27a/granuphilin complex regulates the exocytosis of insulin-containing dense-core granules. Mol. Cell. Biol. 22, 1858-1867.
  • Nagashima K, Torii S, Yi Z, Igarashi M, Okamoto M, Takeuchi T, Izumi T.: Melanophilin directly links Rab27a and myosin Va through its distinct coiled-coil regions. FEBS Lett 517, 233-238.
  • Zhao S, Torii S, Yokota H, Takeuchi T, Izumi T. :Involvement of Rab27b in the regulated secretion of pituitary hormones. Endocrinology 143, 1817-1824.
  • Torii S, Zhao S, Yi Z, Takeuchi T, Izumi T.: Granuphilin modulates the exocytosis of secretory granules through the interaction with syntaxin 1a. Mol. Cell Biol. 22, 5518-5526.
  • Kawamoto K, Yoshida Y, Tamaki H, Torii S, Shinotsuka C, Yamashina S, Nakayama K.: GBF1, a guanine nucleotide exchange factor for ADP-Ribosylation factors, is locallized to the cis-Golgi and involved in membrane association of the COPI coat. Traffic 3, 483-495.
 
 

日本語総説
  • 鳥居征司、竹内利行:膵β細胞における phogrin/IA-2 の役割、糖尿病学2010, 52-57, 2010.
  • 飛田成史、吉原利忠、穂坂正博、竹内利行:りん光分子プローブを用いた癌環境イメージング-低酸素の可視化、Medical Science Digest 35, 538-541, 2009.
  • 渡部 剛、阪井裕子、平義樹、暮地本宙己、穂坂正博:内分泌細胞における分泌顆粒形成機構、顕微鏡 43:29-34, 2008.
  • 穂坂正博: ホルモンが分泌顆粒へ選別されるメカニズム、生化学(社団法人生化学) 79, 166-170, 2007.
  • 河西和雄、鳥居征司、泉哲郎: インスリン分泌顆粒開口放出の分子機序、内分泌・糖尿病科 17, 597-603, 2003.
  • 鳥居征司、泉哲郎: インスリン顆粒の開口放出とグラニュフィリン、分子糖尿病学ー基礎から臨床まで2003 23-27, 2003.

著書
  • 小島至、伴野祥一、竹内利行、柴田宏、穂坂正博、久保原禅、山西哲郎、樋口剛、高橋久仁子 著、群馬に多い病気(コレステロールは悪ものか?)、上毛新聞社・ 2007年
  • 群馬大学教員による共著、新時代への視点(コレステロールと分泌顆粒)、上毛新聞社・2006年